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Optic Nerve Crush in Mice to Study Retinal Ganglion Cell ...

Optic nerve crush (ONC) serves as a useful model not only of traumatic optic neuropathy but also of glaucomato … In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive or regenerate their optic nerve axons underlies partial …

Reproducible Mouse Sciatic Nerve Crush and Subsequent ...

2012-2-22 · The most common instrument used for mouse sciatic nerve crush is the No. 5 angled forceps. While it is possible to obtain a complete crush using this method, we found that this instrument produced a variable crush (too little force …

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Reproducible Mouse Sciatic Nerve Crush and Subsequent ...

2012-2-22 · The most common instrument used for mouse sciatic nerve crush is the No. 5 angled forceps. While it is possible to obtain a complete crush using …

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Optic nerve crush modulates refractive development of the ...

2020-1-1 · Optic nerve crush successfully disrupts retinal connections to higher visual centers. In the mouse, the ophthalmic artery that gives rise to the central retinal artery and capillaries providing blood supply to the retina are close neighbors to (or even enclosing) the optic nerve (May and Lutjen-Drecoll, 2002). In ONS surgery it is thus ...

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A practical approach to optic nerve crush in the mouse

Our goal is to provide an instructional resource to help others wishing to use the optic nerve crush (ONC) as an experimental procedure. The process is described beginning with the anesthesia, followed by positioning of the mouse, the surgery itself, and …

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Reproducible Mouse Sciatic Nerve Crush and Subsequent ...

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Reproducible mouse sciatic nerve crush and subsequent ...

Rats have generally been the preferred animal models for experimental nerve crush. They are widely available and their lesioned sciatic nerve provides a reasonable approximation of human nerve lesions(5,4). Though smaller in size than rat nerve, the …

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Mouse model of muscle crush injury of the legs

Both open and closed small-animal models of skeletal muscle crush injury are available but are limited by their need for surgical isolation of the muscle or by the adverse effect of fibular fracture, respectively. In the current study, we developed and validated a novel, noninvasive mouse model of lower-extremity muscle crush injury.

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Utilizing mouse optic nerve crush to examine CNS ...

2021-9-17 · Mouse eye appears cloudy/opaque in the days following the ONC (End of Part 3, Optic Nerve Crush). Potential solution Cloudy eyes …