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The Role of Hypothalamic Pathology for Non-Motor … 2019-10-24 · In HD, there is a 38% reduction in the number of orexin (hypocretin) immunopositive-neurons in HD and mRNA levels are also diminished compared to control cases [35, 50–52]. Orexin is a neuropeptide that is only expressed in the LHA and it plays an important role in the regulation of sleep, emotion and metabolism [ 53, 54 ]. consult
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